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产品名称:
Eliglustat hemitartrate 依利格鲁司特酒石酸盐
NO.
70
货号
CST11176
中文名称
依利格鲁司特酒石酸盐
英文名称
Eliglustat hemitartrate
CAS号
928659-70-5
产品货号:
CST11176
货期:
现货
价格与订购:
1200.00
数量
-
+
库存
5
产品信息
如何订购
产品描述icon
Eliglustat Hemitartrate, with an IC50 of 24 nM, is a specific, potent, oral active glucocerebral glycosidase inhibitor.
体外活性icon
Eliglustat tartrate shows good potency with an IC50 of 24 nM and specificity against the target enzyme.
体内活性icon
A novel inhibitor of glucosylceramide synthase (Genz-112638) and assessed its activity in a murine model of Gaucher disease (D409V/null).?Biochemical characterization of Genz-112638 showed good potency (IC(50) approximately 24nM) and specificity against the target enzyme.?Mice that received drug prior to significant accumulation of substrate (10 weeks of age) showed reduced levels of glucosylceramide and number of Gaucher cells in the spleen, lung and liver when compared to age-matched control animals.?Treatment of older mice that already displayed significant amounts of tissue glucosylceramide (7 months old) resulted in arrest of further accumulation of the substrate and appearance of additional Gaucher cells in affected organs.?These data indicate that substrate inhibition therapy with Genz-112638 represents a viable alternate approach to enzyme therapy to treat the visceral pathology in Gaucher disease.
分子式icon
C27H42N2O10
分子量icon
554.63
别名icon
Genz-112638;依利格鲁司特酒石酸盐;Eliglustat tartrate
参考文献icon
[1]McEachern KA, et al. A specific and potent inhibitor of glucosylceramide synthase for substrate inhibition therapy ofGaucher disease. Mol Genet Metab. 2007 Jul;91(3):259-67.
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储存和溶解度
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H2O:50 mg/mL (52.13 mM)
DMSO:50 mg/mL (52.13 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Note
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For Research Use Only.
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Eliglustat 依利格鲁司特
EZM0414
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