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Research Grade Ramucirumab ( 雷莫芦单抗 )
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产品名称:

Research Grade Ramucirumab ( 雷莫芦单抗 )

NO.
195
货号:
CSD00194
中文名称
雷莫芦单抗
英文名词
Research Grade Ramucirumab
CAS号
15966-93-5
产品货号:
CSD00194
货期:
现货
价格与订购:
2480.00
数量
-
+
库存:
100
没有此类产品
产品信息
如何订购
货号(Catalog No.)icon
CSD00194
纯度(Purity)icon
>95%
浓度( Concentration)icon
1mg/ml
Formulationicon
PBS buffer PH7.5
Sourceicon
CHO cells
内毒素(Endotoxin level)icon
Please contact with the lab for this information.
产品描述(Description)icon
Ramucirumab is a human monoclonal antibody (IgG1) against vascular endothelial growth factor receptor 2 (VEGFR2), a type II trans-membrane tyrosine kinase receptor expressed on endothelial cells. By binding to VEGFR2, ramucirumab prevents binding of its ligands (VEGF-A, VEGF-C, and VEGF-D), thereby preventing VEGF-stimulated receptor phosphorylation and downstream ligand-induced proliferation, permeability, and migration of human endothelial cells. VEGFR stimulation also mediates downstream signalling required for angiogenesis and is postulated to be heavily involved in cancer progression, making it a highly likely drug target. In contrast to other agents directed against VEGFR-2, ramucirumab binds a specific epitope on the extracellular domain of VEGFR-2, thereby blocking all VEGF ligands from binding to it. Ramucirumab is indicated for us in advanced gastric or gastro-esophageal junction adenocarcinoma as a single agent or in combination with paclitaxel after prior fluoropyrimidine- or platinum-containing chemotherapy.
别名(Alternative names)icon
1121B,IMC-1121B,LY3009806
靶点;物种(Specificity target name;species)icon
KDR/CD309[Homo sapiens]
活性研究(体外/体内研究)(Activity in vitro)icon
3-Substituted indolin-2-ones have been designed and synthesized as a novel class of tyrosine kinase inhibitors which exhibit selectivity toward different receptor tyrosine kinases (RTKs). These compounds have been evaluated for their relative inhibitory properties against a panel of RTKs in intact cells. SU5408 (VEGFR2 Kinase Inhibitor I) is found to be the most potent and selective VEGFR2 inhibitor among the compounds. SU5408 (VEGFR2 Kinase Inhibitor I) shows little or no effect against receptors for platelet-derived growth factor, epidermal growth factor, or insulin-like growth factor (IC50>100 µM).
种类(Species)icon
Homo sapiens
受体鉴定(Receptor identification)icon
IgG1-kappa
分子量(MV)icon
143600.0 Da
CASicon
15966-93-5
存储条件(Storage)icon
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Store at +4°C short term (1-2 weeks).
Store at -20 °C 12 months.
Store at -80°C long term.
Noteicon
For research use only .
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