搜索

159-2642-3062

服务热线(工作日:9:00-17:30)

武汉科斯坦生物科技有限公司

热搜词:燕窝酸,不饱和脂肪酸,神经酰胺,花青素,黄酮,皂苷

Wuhan Chemstan Biotechnology Co., Ltd.

武汉科斯坦生物科技有限公司

代谢组学

科研服务

抗体/蛋白

地       址:武汉市东湖新技术开发区高新大道666号,武汉

                 国家生物产业基地B、C、D区研发楼C1栋
产品销售:15926423062
技术服务:18971263062                                             
E - mail :
info@chemstan.com       
邮       编:430075

化合物单体

科斯坦生物(Chemstan)所有产品和服务仅用于科学研究,不为任何个人或者非科研性质的用途提供产品和服务。

Copyright @ 武汉科斯坦生物科技有限公司.All rights reserved

网站建设:中企动力武汉鄂ICP备19006850号-1

>
>
>
Research Grade Figitumumab ( 芬妥木单抗 )
浏览量:
产品名称:

Research Grade Figitumumab ( 芬妥木单抗 )

NO.
194
货号:
CSD00192
中文名称
芬妥木单抗
英文名词
Research Grade Figitumumab
CAS号
943453-46-1
产品货号:
CSD00192
货期:
现货
价格与订购:
2480.00
数量
-
+
库存:
100
没有此类产品
产品信息
如何订购
货号(Catalog No.)icon
CSD00192
通用名INNicon
Figitumumab
纯度(Purity)icon
>95%
浓度( Concentration)icon
1mg/ml
Formulationicon
PBS buffer PH7.5
Sourceicon
CHO cells
内毒素(Endotoxin level)icon
Please contact with the lab for this information.
产品描述(Description)icon
Figitumumab has been used in trials studying the treatment of Sarcoma, Solid Tumor, Breast Cancer, Lung Neoplasms, and Advanced Cancer, among others.
别名(Alternative names)icon
CP-751871
靶点;物种(Specificity target name;species)icon
IGF1R/CD221[Homo sapiens]
活性研究(体外/体内研究)(Activity in vitro)icon
BMS-754807 effectively inhibits the growth of a broad range of human tumor cell lines with IC50 values of ranging from 5 to 365 nM. BMS-754807 also inhibits the proliferation of human rhabdomyosarcoma tumor cells Rh41 and human colon carcinoma Geo with IC50s of 7 and 5 nM, respectively. BMS-754807 shows inhibitory activity in the proliferation of Rh41 cells with IC50 of 5 nM. BMS-754807 inhibits the phosphorylation of IGF-1R (IC50=13 nM) and the downstream targets Akt (IC50=22 nM) and MAPK (IC50=13 nM) in the IGF-Sal cell line with IC50 consistent with the antiproliferative IC50 (7 nM) in this cell line. BMS-754807 shows a median EC50 value of 0.62 μM against the PPTP cell lines. The median EC50 for the four Ewing sarcoma cell lines is less than that for the remaining PPTP cell lines (0.19 μM vs. 0.78 μM, P=0.0470). BMS-754807 (0.25 and 0.5 μM) reduces the activated IGF-IR/IR (pIGF-IR/IR), causes a concurrent decrease in phosphorylated AKT in both lung cancer cell lines. BMS-754807 (0.5 μM) also reduces wound closure of lung cancer cells and reduces the ERK phosphorylation. BMS-754807 reduces cell viability in both A549 and NCI-H358 cells, with IC50 of 1.08 μM and 76 μM, respectively.
种类(Species)icon
Homo sapiens
受体鉴定(Receptor identification)icon
IgG2-kappa
CASicon
943453-46-1
存储条件(Storage)icon
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Store at +4°C short term (1-2 weeks).
Store at -20 °C 12 months.
Store at -80°C long term.
Noteicon
For research use only .
未找到相应参数组,请于后台属性模板中添加
暂未实现,敬请期待
暂未实现,敬请期待
上一篇
下一篇