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代谢组学
科研服务
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地 址:武汉市东湖新技术开发区高新大道666号,武汉
国家生物产业基地B、C、D区研发楼C1栋
产品销售:15926423062
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E - mail :info@chemstan.com
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产品名称:
Anti SMAD4(D351H) Mouse Monoclonal Antibody
NO.
货号:
CST26418
中文名称
Anti SMAD4(D351H) Mouse Monoclonal Antibody
英文名词
Anti SMAD4(D351H) Mouse Monoclonal Antibody
CAS号
产品货号:
CST26418
货期:
现货
价格与订购:
4800.00
数量:
-
+
库存:
5
产品信息
如何订购
Catalog Numbericon
CST26418
Gene Symbolicon
SMAD4, DPC4, JIP, MADH4, MYHRS
iconicon
Descriptionicon
Anti SMAD4(D351H) Mouse Monoclonal Antibody
Backgroundicon
SMAD4 family member 4, also known as SMAD4, is a protein that in human is encoded by the SMAD4 gene. It is often found mutated in many cancers. It acts as a tumor suppressor that functions in the regulation of the TGF-? signal transduction pathway, which negatively regulates growth of epithelial cells and the extracellular matrix (ECM). SMAD4 alterations have been found in multiploid colorectal cancer and pancreatic carcinoma. It is found inactivated in at least 50% of pancreatic cancers. It is also found mutated in the autosomal dominantdisease juvenile polyposis syndrome (JPS).
Immunogenicon
A synthetic peptide from the internal region of SMAD4 which includes the mutation of D351H, human origin.
Applicationsicon
ELISA, WB, IHC
Recommended Dilutionsicon
ELISA: 1:1000-1:2000
WB: 1:500-1:1000
IHC: 1:50-1:100
Concentrationicon
1 mg/ml
Hosticon
mouse
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Formaticon
Liquid
Clonalityicon
Monoclonal
Purityicon
Purified from ascites
Preservativeicon
no
Constituentsicon
PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol
Species Reactivityicon
Recognizes D351H mutant, but not wild-type SMAD4 of vertebrates.
Immunoprecipitation/Western Blot
icon
icon

Western blot analysis of recombinant SMAD4(D351H) and wildtype proteins. Purified His-tagged SMAD4(D351H) protein (lane1) and corresponding wild-type protein (1-552aa, 65kd) (lane2) were blotted with anti SMAD4(D351H) monoclonal antibody (Cat. #26418).
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Immunofluorescence: icon

Immunofluorescence of cells expressing SMAD4 proteins with anti SMAD4(D351H) antibody. HEK293T cells were transfected with pCDNA3-GFP SMAD4(D351H) plasmid , pCDNA3-GFP SMAD4(WT) plasmid or pCDNA3-GFP SMAD4(D351N) plasmid, then fixed and stained with anti SMAD4(D351H) monoclonal antibody (Cat. #26418).
iconicon
Storage Conditionsicon
Store at -20°C. Avoid freeze / thaw cycles
iconiconicon
Noteicon
For Research Use Only.
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