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Wuhan Chemstan Biotechnology Co., Ltd.
武汉科斯坦生物科技有限公司
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产品名称：
Anti RAS(A146V) Mouse Monoclonal Antibody
NO.
货号：
CST26479
中文名称
Anti RAS(A146V) Mouse Monoclonal Antibody
英文名词
Anti RAS(A146V) Mouse Monoclonal Antibody
CAS号
产品货号：
CST26479
货期：
现货
价格与订购：
4800.00
数量：
-
+
库存：
5
产品信息
如何订购
Catalog Numbericon
CST26479
Gene Symbolicon
H-Ras; K-Ras; N-Ras
iconicon
Descriptionicon
Anti RAS(A146V) Mouse Monoclonal Antibody
Backgroundicon
The A146V mutation of KRas results in an amino acid substitution at position 146, from an alanine to a threonine. KRAS encodes a protein that is a member of the small GTPase superfamily. Ras A146V mutation results in decreased GTPase activity and constitutive signaling. It can be found in many tumors, such as lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma.
Immunogenicon
A synthetic peptide from the internal region of Ras which includes the mutation of A146V, human origin.
Applicationsicon
ELISA, WB, IHC
Recommended Dilutionsicon
ELISA: 1:1000-1:5000
WB: 1:500-1:1000
IHC: 1:50-1:100
Concentrationicon
1 mg/ml
Hosticon
mouse
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Formaticon
Liquid
Clonalityicon
Monoclonal
Purityicon
Purified from ascites
Preservativeicon
no
Constituentsicon
PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol
Species Reactivityicon
Recognizes A146V mutant, but not wild-type RAS of vertebrates.
Immunoprecipitation/Western Blot
icon
icon
Western blot analysis of recombinant RAS(A146V) and wild-type proteins. Purified His-tagged RAS(A146V) protein (lane 1) and corresponding wild-type protein (lane 2) were blotted with Anti RAS(A146V) monoclonal antibody (Cat. #26479).
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Immunofluorescence: icon
Immunofluorescence of cells expressing KRas proteins with anti KRAS(A146V) antibody. HEK293T cells were transfected with pCDNA3-GFP KRAS(A146V) plasmid, pCDNA3-GFP KRas(WT) plasmid, pCDNA3-GFP KRas(A146P) plasmid or pCDNA3-GFP KRas(A146T) plasmid, then fixed and stained with anti KRAS(A146V) monoclonal antibody (Cat. #26479).
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Storage Conditionsicon
Store at -20°C. Avoid freeze / thaw cycles
iconiconicon
Noteicon
For Research Use Only.
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