Recombinant Human PTPRN protein

>90% as determined by SDS-PAGE

Please contact with the lab for this information.

A DNA sequence encoding the human PTPRN (Met389-Arg575) was fused with His tag

Q16849

E.coli

Homo sapiens (Human)

21.16 kDa

Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5.

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.

Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.

Plays a role in vesicle-mediated secretory processes . Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets . Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation . Plays a role in insulin secretion in response to glucose stimuli . Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain . In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) . Required to maintain normal levels of renin expression and renin release . Seems to lack intrinsic enzyme activity . May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization

Receptor-type tyrosine-protein phosphatase-like N,R-PTP-N,Islet cell antigen 512,ICA 512,Islet cell autoantigen 3,PTP IA-2.

For research use only .