Recombinant Human B2M protein,C- His Tag
A DNA sequence encoding the human B2M (Met1~Met119) was fused with the C-terminal His Tag
Please contact with the lab for this information.
Supplied as solution form in PBS, pH7.5/ Supplied as lyophilized from PBS, pH7.5
In general, proteins are shipped out with blue ice unless customers require otherwise.
Please refer to the instraction in the hard copy of COA.
B2M, also known as β2-Microglobulin or CDABP92, is a component of MHC class I molecules found expression in all nucleated cells (excludes red blood cells). The major function of MHC class I moleculesis is to display fragments of proteins from within the cell to T-cells and cells containing foreign proteins will be attacked. B2M(β2-Microglobulin) is a low molecular weight protein. It was demonstrated that B2M(β2-Microglobulin) was localized in the membranes of nucleated cells and was found to be associated with HL-A antigens.B2M(β2- Microglobulin) is present in free form in various body fluids and as a subunit of histocompatibility antigens on cell surfaces lateral to theα3 chain. Unlikeα3, β2 has no transmembrane region. Directly above β2 lies the α1 chain, which itself is lateral to the α2. In the absence of B2M(β2 microglobulin), very limited amounts of MHC class I (classical and non-classical) molecules can be detected on the surface. In the absence of MHC class I, CD8 T cells, a subset of T cells involved in the development of acquired immunity cannot develop. Low levels of B2M(β2 microglobulin) can indicate non-progression of HIV.
This antibody is specific for human interleukin-6
Calibrator or standard in ELISA, WB, IHC and other possible application
Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.