Recombinant Human PIVKA-II/Prothrombin protein,C- His Tag
A DNA sequence encoding the human F2（Met1-Glu622）with C-terminal His Tag
Please contact with the lab for this information.
Supplied as solution form in PBS, pH7.5/ Supplied as lyophilized from PBS, pH7.5
In general, proteins are shipped out with blue ice unless customers require otherwise.
Please refer to the instraction in the hard copy of COA.icon
Calibrator or standard in ELISA, WB, IHC and other possible application
Protein Induced by Vitamin K Absence or Antagonist-II (PIVKA-II), also known as Des-γ-carboxy-prothrombin (DCP), is an abnormal form of prothrombin. Normally, the prothrombin’s 10 glutamic acid residues (Glu) in the γ-carboxyglutamic acid (Gla) domain at positions 6, 7, 14, 16, 19, 20,25, 26, 29 and 32 are γ-carboxylated to Gla by vitamin-K dependent γ- glutamyl carboxylase in the liver and then secreted into plasma. In patients with hepatocellular carcinoma (HCC), γ-carboxylation of prothrombin is impaired so that PIVKA-II is formed instead of prothrombin. PIVKA-II is considered as is an efficient biomarker specific for HCC