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  • 产品名称: Research Grade Dinutuximab ( 地努妥昔单抗 )
  • 产品货号: CSD00319
  • 货期: 现货
  • 价格与订购: 2480
  • 数量:
    库存: 100
  • 规格: 100μg
  • 产品信息
  • 如何订购
    货号(Catalog No.)
    CSD00319
    通用名INN
    Dinutuximab
    纯度(Purity)
    >95%
    电泳图(SDS-PAGE image)

    icon
    浓度( Concentration)
    1mg/ml
    Formulation
    PBS buffer PH7.5
    Source
    CHO cells
    内毒素(Endotoxin level)
    Please contact with the lab for this information.
    产品描述(Description)
    Dinutuximab is an IgG1 monoclonal human/mouse chimeric antibody against GD2, a disialoganglioside expressed on tumors of neuroectodermal origin, including human neuroblastoma and melanoma, with highly restricted expression on normal tissues. It is composed of the variable heavy- and light-chain regions of the murine anti-GD2 mAb 14.18 and the constant regions of human IgG1 heavy-chain and kappa light-chain. By binding to GD2, dinutiximab induces antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity of tumor cells thereby leading to apoptosis and inhibiting proliferation of the tumour. It is indicated, in combination with granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-2 (IL-2), and 13-cis-retinoic acid (RA), for the treatment of pediatric patients with high-risk neuroblastoma who achieve at least a partial response to prior first-line multiagent, multimodality therapy. Despite a high clinical response seen after first-line treatment, the complete eradication of neuroblastoma is rarely achieved and the majority of patients with advanced disease suffer a relapse. Current strategies for treatment include immunotherapy with drugs such as dinutuximab to target surviving neuroblastoma cells and to prevent relapse.
    别名(Alternative names)
    14.18,MAb-14.18,MOAB Ch14.18
    靶点;物种(Specificity target name;species)
    ganglioside GD2[Homo sapiens]
    种类(Species)
    Chimeric
    受体鉴定(Receptor identification)
    IgG1-kappa
    分子量(MV)
    145000.0 Da
    CAS
    1363687-32-4
    存储条件(Storage)
    Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
    Store at +4°C short term (1-2 weeks).
    Store at -20 °C 12 months.
    Store at -80°C long term.
    Note
    For research use only .