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Research Grade Dinutuximab ( 地努妥昔单抗 )
浏览量:
产品名称:

Research Grade Dinutuximab ( 地努妥昔单抗 )

NO.
309
货号:
CSD00319
中文名称
地努妥昔单抗
英文名词
Research Grade Dinutuximab
CAS号
1363687-32-4
产品货号:
CSD00319
货期:
现货
价格与订购:
2480.00
数量
-
+
库存:
100
没有此类产品
产品信息
如何订购
货号(Catalog No.)icon
CSD00319
通用名INNicon
Dinutuximab
纯度(Purity)icon
>95%
电泳图(SDS-PAGE image)
icon

icon
浓度( Concentration)icon
1mg/ml
Formulationicon
PBS buffer PH7.5
Sourceicon
CHO cells
内毒素(Endotoxin level)icon
Please contact with the lab for this information.
产品描述(Description)icon
Dinutuximab is an IgG1 monoclonal human/mouse chimeric antibody against GD2, a disialoganglioside expressed on tumors of neuroectodermal origin, including human neuroblastoma and melanoma, with highly restricted expression on normal tissues. It is composed of the variable heavy- and light-chain regions of the murine anti-GD2 mAb 14.18 and the constant regions of human IgG1 heavy-chain and kappa light-chain. By binding to GD2, dinutiximab induces antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity of tumor cells thereby leading to apoptosis and inhibiting proliferation of the tumour. It is indicated, in combination with granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-2 (IL-2), and 13-cis-retinoic acid (RA), for the treatment of pediatric patients with high-risk neuroblastoma who achieve at least a partial response to prior first-line multiagent, multimodality therapy. Despite a high clinical response seen after first-line treatment, the complete eradication of neuroblastoma is rarely achieved and the majority of patients with advanced disease suffer a relapse. Current strategies for treatment include immunotherapy with drugs such as dinutuximab to target surviving neuroblastoma cells and to prevent relapse.
别名(Alternative names)icon
14.18,MAb-14.18,MOAB Ch14.18
靶点;物种(Specificity target name;species)icon
ganglioside GD2[Homo sapiens]
种类(Species)icon
Chimeric
受体鉴定(Receptor identification)icon
IgG1-kappa
分子量(MV)icon
145000.0 Da
CASicon
1363687-32-4
存储条件(Storage)icon
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Store at +4°C short term (1-2 weeks).
Store at -20 °C 12 months.
Store at -80°C long term.
Noteicon
For research use only .
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