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Research Grade Idarucizumab ( 艾达赛珠单抗 )
浏览量:
产品名称:

Research Grade Idarucizumab ( 艾达赛珠单抗 )

NO.
307
货号:
CSD00317
中文名称
艾达赛珠单抗
英文名词
Research Grade Idarucizumab
CAS号
1362509-93-0
产品货号:
CSD00317
货期:
现货
价格与订购:
2480.00
数量
-
+
库存:
100
没有此类产品
产品信息
如何订购
货号(Catalog No.)icon
CSD00317
通用名INNicon
Idarucizumab
纯度(Purity)icon
>95%
浓度( Concentration)icon
1mg/ml
Formulationicon
PBS buffer PH7.5
Sourceicon
CHO cells
内毒素(Endotoxin level)icon
Please contact with the lab for this information.
产品描述(Description)icon
Idarucizumab is a humanized monoclonal antibody fragment (Fab) derived from an immunoglobulin G1 isotype molecule that binds to and inactivates the oral anticoagulant dabigatran, thereby reversing its anticoagulant effect. As a direct acting oral anticoagulant (DOAC), one of the risks associated with the use of dabigatran includes bleeding, espeically when given to patients at increased risk (elderly, chronic kidney disease, concomitant NSAID or warfarin use, etc).Approved under the tradename Praxbind (FDA), idarucizumab is indicated for the emergency treatment of dabigatran-associated bleeding in life-threatening or surgically induced situations. Its use is associated with immediate, complete and sustained reversal of the anticoagulant effects of dabigatran.Idarucizumab protein structure can be viewed below, with disulfide bridges at the following points: H22-H95, H149-H205, H225-L-219, L23-L93, L139-L199.
别名(Alternative names)icon
aDabi-Fab,anti-dabigatran,antidote for dabigatran
靶点;物种(Specificity target name;species)icon
MS4A1[Homo sapiens]
活性研究(体外/体内研究)(Activity in vitro)icon
Dabigatran selectively and reversibly inhibited human thrombin(Ki: 4.5 nM) as well as thrombin-induced platelet aggregation (IC50: 10 nM), while showing no inhibitory effect on other platelet-stimulating agents. Thrombin generation in platelet-poor plasma (PPP), measured as the endogenous thrombin potential (ETP) was inhibited concentration-dependently (IC50: 0.56 μM). Dabigatran demonstrated concentration-dependent anticoagulant effects in various species in vitro, doubling the activated partial thromboplastin time (aPTT), prothrombin time (PT) and ecarin clotting time (ECT) in human PPP at concentrations of 0.23, 0.83 and 0.18 μM, respectively.
种类(Species)icon
Humanized
受体鉴定(Receptor identification)icon
Fab
CASicon
1362509-93-0
存储条件(Storage)icon
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Store at +4°C short term (1-2 weeks).
Store at -20 °C 12 months.
Store at -80°C long term.
Noteicon
For research use only .
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