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  • 产品名称: Research Grade Ocaratuzumab ( 奥卡妥珠单抗 )
  • 产品货号: CSD00293
  • 货期: 现货
  • 价格与订购: 2480
  • 数量:
    库存: 100
  • 规格: 100μg
  • 产品信息
  • 如何订购
    货号(Catalog No.)
    CSD00293
    通用名INN
    Ocaratuzumab
    纯度(Purity)
    >95%
    浓度( Concentration)
    1mg/ml
    Formulation
    PBS buffer PH7.5
    Source
    CHO cells
    内毒素(Endotoxin level)
    Please contact with the lab for this information.
    别名(Alternative names)
    AME-133v,LY2469298
    靶点;物种(Specificity target name;species)
    MS4A1/CD20[Homo sapiens]
    活性研究(体外/体内研究)(Activity in vitro)
    Complement-dependent cytotoxicity(CDC), complement-dependent cellular cytotoxicity(CDCC), antibody-dependent cytotoxicity (ADCC) as well as the induction of apoptosis have been claimed to be responsible for the efficacy of rituximab. Rituximab can induce death of malignant B cell lines in vitro. Th strength of this effect varies considerably between target cell lines. Changes that have been identified in response to rituximab in vitro include inhibition of p38 mitogen-activated protein kinase, NF-κB, extracellular signal-regulated kinase 1/2 (ERK 1/2) and AKT antiapoptotic survival pathways. Rituximab is highly efficient at mediating CMC(complement dependent cytotoxicity) of various B cell lines as well as fresh malignant B cell samples. CD20-binding capacity of rituximab is dose-dependentv.
    种类(Species)
    Humanized
    受体鉴定(Receptor identification)
    IgG1-kappa
    CAS
    1169956-08-4
    存储条件(Storage)
    Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
    Store at +4°C short term (1-2 weeks).
    Store at -20 °C 12 months.
    Store at -80°C long term.
    Note
    For research use only .