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  • 产品名称: Anti TMPRSS2 polyclonal antibody
  • 产品货号: CSP226
  • 货期: 现货
  • 价格与订购: 2880
  • 数量:
    库存: 100
  • 规格:
  • 产品信息
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    产品名称(Product name)
    Anti TMPRSS2 polyclonal antibody
    货号(Catalog#)
    CSP226icon
    描述(description)
    Produced in rabbits immunized with purified,Recombinant Human TMPRSS2 protein
    Accession #
    O15393
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    别名(Alternative names)
    PP9284, PRSS10, Serine protease 10, TMPRSS2
    稳定性&储存(Stability &Storage)
    Use a manual defrost freezer and avoid repeated freeze thaw cycles.
    Store at 2 to 8 °C for one week .
    Store at -20 to -80 °C for twelve months from the date of receipt.
    特异性(Spcificty)
    Recognizes Human TMPRSS2 protein
    亚型(Isotype)
    IgG
    宿主(Host)
    Rabbit
    克隆性(Clonality)
    Polyclonal
    偶连物(Conjugation)
    Unconjugate
    种属反应性(Species reactivity)
    Human,other species was not test
    应用实验(Tested applications)
    WB,IHCiconiconicon
    免疫原(Immunogen)
    Recombinant Human TMPRSS2 protein
    背景(Background)
    TMPRSS2, also named as PRSS10, is a type II transmembrane serine protease which is highly expressed by the epithelium of the human prostate gland. TMPRSS2 may contribute to prostate tumour metastasis via the activation of PAR-2. TMPRSS2 is a Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions. TMPRSS2 as a host cell factor that is critical for spread of several clinically relevant viruses, including influenza A viruses and coronaviruses.SARS-CoV-2 uses the SARS-CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming. The initial spike protein priming by TMPRSS2 is essential for entry and viral spread of SARS-CoV-2 through interaction with the ACE2 receptor.Camostat mesylate, an inhibitor of TMPRSS2, can block SARS-CoV-2 infection of lung cells.The MW of TMPRSS2 is about 65-70 kDa. It can be cleaved in to some chains with MW 54 kDa, 31 kDa and 26 kDaicon
    状态(Form)
    Liquidicon
    储存溶液(Buffer)
    PBS,pH7.4,containing 0.05% proclin300,50% glycerol.
    浓度(Concentration)
    0.5mg/mliconicon
    分子量(MW)
    54kDa
    应用实验及稀释比例(Dilution Range)
    WB:1:2000-1:8000,IHC:1:200-1:400
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    Note
    For research use only .