Anti SARS-CoV-2(2019-nCoV) NSP3 polyclonal antibody
Produced in rabbits immunized with purified,Recombinant SARS-CoV-2 NSP3 protein
Recognizes SARS-CoV-2 NSP3 protein
Non-structural protein 3,PL2-PRO,Papain-like proteinase,PL-PRO,Replicase polyprotein 1a
Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2)
Recombinant SARS-CoV-2 NSP3(Glu1024-Gln1198)
Responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Participates together with nsp4 in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF3. Prevents also host NF-kappa-B signaling.
Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.
PBS, pH7.4, containing 0.05% proclin300, 50% glycerol.