159-2642-3062 027-6531779
服务热线(工作日:9:00-17:30)

浏览量: 20

  • 产品名称: Research Grade Quilizumab ( 奎利珠单抗 )
  • 产品货号: CSD00277
  • 货期: 现货
  • 价格与订购: 2480
  • 数量:
    库存: 100
  • 规格: 100μg
  • 产品信息
  • 如何订购
    货号(Catalog No.)
    CSD00277
    通用名INN
    Quilizumab
    纯度(Purity)
    >95%
    浓度( Concentration)
    1mg/ml
    Formulation
    PBS buffer PH7.5
    Source
    CHO cells
    内毒素(Endotoxin level)
    Please contact with the lab for this information.
    产品描述(Description)
    Quilizumab is under investigation in clinical trial NCT01160861 (A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of MEMP1972A in Patients With Allergic Rhinitis).
    别名(Alternative names)
    47H4,Anti-M1 prime,MEMP1972A,RG-7449
    靶点;物种(Specificity target name;species)
    IGHE[Homo sapiens]
    活性研究(体外/体内研究)(Activity in vitro)
    KW-2478 inhibits the binding of bRD to Hsp90α with IC50 of 3.8 nM. KW-2478 degradates the Hsp90 client proteins, including FGFR3 and IGF-1Rβand c-Raf-1. KW-2478 reduces the level of phosphorylated Erk1/2. KW-2478 induces apoptosis by cleavage of PARP, a substrate of caspase-3 In U266 cells,. KW-2478 has Time dependency of antiproliferative activity, consecutive drug exposure for at least 12 hours is necessary to to exert potent antitumor activity. KW-2478 downregulates the translocation products of IgH locus. KW-2478 inhibits the transcription of c-Maf and cyclin D1 genes by mainly suppressing the function of Cdk9. KW-2478 has potent and broad growth inhibitory activities against various cell lines, KW-2478 inhibites cancer cell growth in all cell lines, with EC50 of 101-252 nM, 81.4-91.4 nM and 120-622 nM for B-cell lymphoma, mantle cell lymphoma and multiple myeloma, respectively. KW-2478 also shows potent growth inhibitory activity in primary CLL and NHL cells with EC50 of 40-170 nM and 200-400 nM, respectively.
    种类(Species)
    Humanized
    受体鉴定(Receptor identification)
    IgG1-kappa
    CAS
    1228538-47-3
    存储条件(Storage)
    Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
    Store at +4°C short term (1-2 weeks).
    Store at -20 °C 12 months.
    Store at -80°C long term.
    Note
    For research use only .