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武汉科斯坦生物科技有限公司
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科研服务
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地 址:武汉市东湖新技术开发区高新大道666号,武汉
国家生物产业基地B、C、D区研发楼C1栋
产品销售:15926423062
技术服务:18971263062
E - mail :info@chemstan.com
邮 编:430075
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产品名称:
Research Grade Narnatumab ( 那呐妥单抗 )
NO.
258
货号:
CSD00263
中文名称
那呐妥单抗
英文名词
Research Grade Narnatumab
CAS号
1188275-92-4
产品货号:
CSD00263
货期:
现货
价格与订购:
2480.00
数量:
-
+
库存:
100
产品信息
如何订购
货号(Catalog No.)icon
CSD00263
通用名INNicon
Narnatumab
纯度(Purity)icon
>95%
浓度( Concentration)icon
1mg/ml
Formulationicon
PBS buffer PH7.5
Sourceicon
CHO cells
内毒素(Endotoxin level)icon
Please contact with the lab for this information.
产品描述(Description)icon
Narnatumab is under investigation in clinical trial NCT01119456 (A Study of IMC-RON8 in Advanced Solid Tumors).
别名(Alternative names)icon
IMC RON-8,RON8
靶点;物种(Specificity target name;species)icon
MST1R/CD136[Homo sapiens]
活性研究(体外/体内研究)(Activity in vitro)icon
LY2801653 demonstrates in vitro effects on MET pathway-dependent cell scattering and cell proliferation. It demonstrates more potent anti-proliferative activity in cell lines with MET gene amplification (MKN45, Hs746T and H1993) than the cell lines without MET gene amplification (U-87MG, KATO-III). LY2801653 also maintains potency against 13 MET variants, each bearing a single-point mutation. It is found to have potent activity against several other receptor tyrosine oncokinases including MST1R, FLT3, AXL, MERTK, TEK, ROS1, DDR1/2 and against the serine/threonine kinases MKNK1/2. The mean IC50 value of LY2801653 for inhibition of MET auto-phosphorylation in HGF-stimulated H460 cells is 35.2±6.9 nM and the IC50 for MET auto-phosphorylation in S114 cells is 59.2 nM.
种类(Species)icon
Homo sapiens
受体鉴定(Receptor identification)icon
IgG1-kappa
分子量(MV)icon
148000.00 Da
CASicon
1188275-92-4
存储条件(Storage)icon
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Store at +4°C short term (1-2 weeks).
Store at -20 °C 12 months.
Store at -80°C long term.
Noteicon
For research use only .
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