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武汉科斯坦生物科技有限公司
热搜词：燕窝酸，不饱和脂肪酸，神经酰胺，花青素，黄酮，皂苷
Wuhan Chemstan Biotechnology Co., Ltd.
武汉科斯坦生物科技有限公司
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产品名称：
Research Grade Vedolizumab ( 维多组单抗 )
NO.
198
货号：
CSD00198
中文名称
维多组单抗
英文名词
Research Grade Vedolizumab
CAS号
943609-66-3
产品货号：
CSD00198
货期：
现货
价格与订购：
2480.00
数量：
-
+
库存：
100
产品信息
如何订购
货号（Catalog No.）icon
CSD00198
通用名INNicon
Vedolizumab
纯度(Purity)icon
>95%
浓度( Concentration)icon
1mg/ml
Formulationicon
PBS buffer PH7.5
Sourceicon
CHO cells
内毒素(Endotoxin level)icon
Please contact with the lab for this information.
产品描述(Description)icon
Vedolizumab is a humanized monoclonal antibody that targets the α4β7 integrin for the treatment of ulcerative colitis and Crohn's disease.
别名(Alternative names)icon
LDP-02,LDP02,MLN-02,MLN0002,MLN02
靶点;物种(Specificity target name;species)icon
ITGA4_ITGB7[Homo sapiens]
活性研究（体外/体内研究）(Activity in vitro)icon
Vedolizumab does not bind to the majority of memory CD4+ T lymphocytes (60%), neutrophils, and most monocytes. The highest level of vedolizumab binding is to a subset (25%) of human peripheral blood memory CD4+ T lymphocytes that include gut-homing interleukin 17 T-helper lymphocytes. Vedolizumab also binds to eosinophils at high levels, and to naive T-helper lymphocytes, naive and memory cytotoxic T lymphocytes, B lymphocytes, natural killer cells, and basophils at lower levels; vedolizumab binds to memory CD4+ T and B lymphocytes with subnanomolar potency (EC50=0.3-0.4 nM). Vedolizumab selectively inhibits adhesion of α4β7-expressing cells to mucosal addressin cell adhesion molecule 1 (IC50=0.02-0.06 g/mL) and fibronectin (IC50=0.02 g/mL), but not vascular cell adhesion molecule 1.
种类(Species)icon
Humanized
受体鉴定(Receptor identification)icon
IgG1-kappa
分子量(MV)icon
146814.9 Da
CASicon
943609-66-3
存储条件(Storage)icon
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Store at +4°C short term (1-2 weeks).
Store at -20 °C 12 months.
Store at -80°C long term.
Noteicon
For research use only .
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