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  • 产品名称: Recombinant SARS-CoV-2(2019-nCoV) S +E +M protein
  • 产品货号: CSEP02447COV
  • 货期: 现货
  • 价格与订购: 2880
  • 数量:
    库存: 100
  • 规格:
  • 产品信息
  • 如何订购
    产品名称(Product name)
    Recombinant SARS-CoV-2(2019-nCoV) S +E +M protein
    货号(Catalog#)
    CSEP02447COV
    描述(description)
    Recombinant SARS-CoV-2 S&M&E fusion is produced by E.coli expression system and the target gene encoding Arg319-Phe541&Arg38-Val75&Arg101-Gln222 is expressed with C-His Tag
    表达系统(Expression system)
    E.coli
    种属(Species)
    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
    Accession #
    别名(Alternative names)
    Spike glycoprotein;Envelope small membrane protein, E protein;Membrane protein
    预测分子量(Predicted Molecular Mass)
    44.7kDa
    纯度(Purity)
    >90% as determined by SDS-PAGE
    内毒素(Endotoxin level)
    Please contact with the lab for this information
    制剂(Formulation)
    Supplied as solution form in PBS, pH7.5 or lyophilized from PBS, pH7.5
    运输方式(Shipping)
    In general, proteins are shipped out with blue ice unless customers require otherwise.
    稳定性&储存(Stability &Storage)
    Use a manual defrost freezer and avoid repeated freeze thaw cycles.
    Store at 2 to 8 °C for one week .
    Store at -20 to -80 °C for twelve months from the date of receipt.
    复溶(Reconstitution)

      Please refer to the instraction in the hard copy of COA.

    应用(Application)
    Immunogen
    背景(Background)
    Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
     
    Coronavirus envelope (E) proteins are short (100 residues) polypeptides that contain at least one transmembrane (TM) domain and a cluster of 2-3 juxtamembrane cysteines. These proteins are involved in viral morphogenesis and tropism, and their absence leads in some cases to aberrant virions, or to viral attenuation. In common to other viroporins, coronavirus envelope proteins increase membrane permeability to ions, plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis. Activates the host NLRP3 inflammasome, leading to IL-1beta overproduction.
     
    Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.
    Note
    For research use only .