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- 产品名称： Recombinant Human ELOB/ELOC/VHL Complex Protein
- 产品货号： CS05649
- 货期： 现货
- 价格与订购： 590
- 数量：
库存： 10
- 规格： 10ug 50ug
- 产品信息
- 如何订购
别名
Elongin B & Elongin C & VHL; ELOB & ELOC & VHL Complex; Elongin B & Elongin C & VHL Complex
种属
Human
来源
Baculovirus-Insect Cells
分子量
14 kDa (ElOB) and 13.3 kDa (ElOC) and 25.9 kDa (VHL)
外观
Liquid
形态
40mM Tris, 200mM NaCl, 2.2mM KCl, 20% glycerol, 3mM DTT, pH8.0
序列
ELOB flag tag, Human, Asp2-Gln118, N-flag DYKDDDDKDVFLMIRRHKTTIFTDAKESSTVFELKRIVEGILKRPPDEQRLYKDDQLLDDGKTLGECGFTSQTARPQAPATVGLAFRADDTFEALCIEPFSSPPELPDVMKPQDSGSSANEQAVQ ELOC flag tag, Human, Asp2-Cys112, N-flag DYKDDDDKDGEEKTYGGCEGPDAMYVKLISSDGHEFIVKREHALTSGTIKAMLSGPGQFAENETNEVNFREIPSHVLSKVCMYFTYKVRYTNSSTEIPEFPIAPEIALELLMAANFLDC VHL His tag, Human, Pro2-Asp213, N-His HHHHHHHHHHGGGSGGGSPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGH
LWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD
标签
No Tag
Accession
Q15370
纯度
＞95% by SDS-PAGE
内毒素水平
<0.1EU/ug
溶解方法
N.A
储存/保存方法
Within 1 week, 2 to 8 °C under sterile conditions after reconstitution. 12 months from date of receipt, -20 to -80 °C as supplied. Avoid repeated freeze-thaw cycles.
背景说明
ELOB (elongin B) is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. ELOB and ELOC(elongin C) form a heterodimer that serves as the regulatory subunit for the Elongin complex-a general transcription elongation factor that increases RNA Polymerase II transcription through template-encoded arresting sites. The ELOB/ELOC complex also binds to the "BC-box motif" found in many proteins in the VHL-box and SOCS-box protein families. The VHL(von Hippel-Lindau disease tumor suppressor) binds to ELOB and ELOC and thereby inhibits transcription elongation.
参考文献
1.Cell Chem Biol. 2023 Jul 20;30(7):766-779.e11. Epub 2023 Jun 23.
2.bioRxiv. 2023 May 24;2023.05.22.541439. PreprintOkumura F., et al. (2012) Front. Oncol.
3.Mod Pathol. 2023 Apr 23;36(8):100194. Online ahead of print.
Note
For research use only.
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