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  • 产品名称: Anti-cGMP Mouse Monoclonal Antibody
  • 产品货号: 26001-1
  • 货期: 现货
  • 价格与订购: 2800
  • 数量:
    库存: 5
  • 规格: 100μg
  • 产品信息
  • 如何订购
    Catalog Number
    26001-1 
    Gene Symbol
    CLU
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    Description
     Anti-cGMP Mouse Monoclonal Antibody
    Background
    cGMP is a ubiquitous second  messenger mediating cellular responses to various 
     exogenous and endogenous signaling molecules.  cGMP regulates physiological processes by  
    activating protein kinases, gating specific ion  channels, and modulating cellular cyclic nucleotide concentrations through phosphodiesterases. The  conversion of GTP to cGMP is catalyzed by guanylyl cyclases (GCs). There are two types of  GCs in mammals: the soluble and the  membrane-boundGCs. The soluble GCs are  generally activated when nitric 
    oxide binds to the attached prosthetic heme group. Seven  membrane-bound GCs (also named transmembrane  or particulated GCs) have been identified in the  human genome. GC-A and GC-B are natriuretic  peptide receptors. GC-C can be activated by  bacterial heat-stable enterotoxins,guanylin and  uroguanylin. The activity of transmembrane GCs  can also be modulated by other receptor signals  through intracellular signaling pathways.  
    Immunogen
    cGMP 
    Applications
    ELISA, WB, IHC
    Recommended Dilutions
    ELISA 1:1000-1:5000,  WB 1:1000-1:2000,  
    Host
    Mouse
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    Format
    Liquid
    Clonality
    Monoclonal
    Purity
    Purified from ascites
    Preservative
    no
    Constituents
     PBS (without Mg2+ and Ca2+), pH 7.4icon
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    Storage Conditions
    Store at -20°C. Avoid freeze / thaw cycles
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    Note
    For Research Use Only.